In part two, of this series on the connection between lifestyle, alterations of the microbiome, gut and brain connections and behavioral health, John and Mark examine the literature using fermentable foods and probiotics. In these studies, improvements in mood, anxiety, appetite regulation, cognition, and brain structure-function have been demonstrated. Mark and John summarize lifestyle interventions that can improve behavioral-mental health and allow people to come off or avoid psychtropic drugs, anti-depressants, and anxiolytics.