Cardiovascular Aging and Longevity

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Cardiovascular disease continues to be the #1 cause of mortality in the US and around the world. In this episode of The Health Edge, Mark and John review a paper that begins to address why it is that as we age, our risk for cardiovascular disease (CVD) and all other “age-related diseases” goes up dramatically. In this 2021 paper from the Journal of The American College of Cardiology, inhabitants of the Ikaria Island in Greece, a Blue Zone culture demonstrate lower levels of age-related changes e.g. inflammation, high insulin, short telomeres and offers many reasons for lower CVD risk, mortality and expanded healthspan.

Cardiovascular-Aging-and-Longevity-JACC-State-of-the-Art-ReviewDownload

The Omega-6 to Omega-3 Fat Ratio as a Predictor of Health and Longevity

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In this recording of The Health Edge, Mark and John discuss the importance of dietary intake and sources of omega 6 and omega 3 fats. An abundance of epidemiological and clinical trials suggest high ratios of O-6/O-3 drive increased inflammation, oxidative stress and are associated with increased cardiovascular and all-cause mortality. Mark and John look at the biochemistry and some clinical trials that support avoidance of processed omega-6 vegetable oils and encourage more whole omega-3 sources.
Audio Recording
Use-of-dietary-linoleic-acid-for-secondary-prevention-of-coronary-heart-disease-and-death-evaluation-of-recovered-data-from-the-Sydney-Diet-Heart-Study-and-updated-meta-analysisDownload
A-Low-ω-6-to-ω-3-PUFA-Ratio-n–6-n–3-PUFA-Diet-to-Treat-Fatty-Liver-Disease-in-Obese-YouthDownload
An-Increase-in-the-Omega-6Omega-3-Fatty-Acid-Ratio-Increases-the-Risk-for-ObesityDownload
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The Health Effects of Time in Nature: An interview with Mark Campbell PhD.

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In this recording of The Health Edge, Mark and John interview Mark Campbell PhD. We discuss the science linking time in Nature with global health outcomes. About Mark Campbell: Dr. Mark A. Campbell uses his background in wellness, sports medicine, exercise science, and performance psychology to impact change across all areas of life. His diverse background affords him the ability to help audiences see the world through many lenses. Mark shares his unique blend of holistic education, application, and experience with audiences worldwide. Mark spent almost a decade leading performance and wellness-based programs for the US Army and the Department of Defense, which included assisting the military and government leads from fourteen Allied nations in developing transition programs for their wounded, ill, and injured military populations. He then acted as the Director of Mental Conditioning for the World Series Champion Washington Nationals. Mark holds both the Certified Wellness Practitioner (CWP) and Certified Worksite Wellness Specialist (CWWS) through the National Wellness Institute, were he currently serves as the Senior Fellow for Healthcare and Ability.

https://campbell-performance.com/

https://pubmed.ncbi.nlm.nih.gov/32668…

Cardiometabolic Health: Are you a member of this exclusive club?

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In this episode of The Health Edge Mark and John review a recent study published by the Journal of the American College of Cardiology, Trends and Disparities in Cardiometabolic Health Among U.S. Adults, 1999-2018. Mark and John reflect on how we got here and why this is so important to recognize and respond to. Lifestyle drivers and interventions are discussed that have the potential to powerfully reverse these concerning trends. Article referenced: https://pubmed.ncbi.nlm.nih.gov/35798…

You Tube recording can be found at: https://www.youtube.com/watch?v=_lBUR_llqfA&t=9s&ab_channel=TheHealthEdge

Fructose, Uric acid and Cardiometabolic Risk

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Is it possible that consuming too much fruit could be detrimental to your health? Are all fruits the same? In this recording of The Health Edge Mark and John will explore the relationship between dietary fructose intake (from sugar and high fructose corn syrup and fruits), endogenous metabolic conversion of glucose to fructose (high glycemic foods), and high salt intake (> 5,000 mg sodium/day) with high uric acid cardiometabolic syndrome risk. The evolutionary biologic importance of these pathways as an ancient survival mechanism when food sources were limited has become a major driver of chronic, complex disease in a contemporary context of high sugar and abundant year-round fruit availability. They elaborate on the research of Robert Lustig MD (UCSF), Richard Johnson MD (University of Colorado)and Robert Ludwig MD, PhD (Harvard). Enjoy!

You Tube Video can be seen at: https://youtu.be/jMutUONBt1o
Fructose-insulin-resistance-and-metabolic-dyslipidemiaDownload
The-effects-of-apples-and-apple-juice-on-acute-plasma-uric-acid-concentration-a-randomized-controlled-trialDownload
Fructose-and-Hepatic-Insulin-ResistanceDownload
The-Effect-of-6-months-Fruit-rich-Diet-on-Liver-Steatosis-Liver-Enzymes-Insulin-Resistance-and-Lipid-Profile-in-Patients-With-Non-alcoholic-Fatty-Liver-Disease-a-Randomized-Clinical-TrialDownload
Fructose-Induced-Intestinal-Microbiota-Shift-Following-Two-Types-of-Short-Term-High-Fructose-Dietary-PhasesDownload
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Can Vitamin D supplementation slow biologic age?

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In this episode of The Health Edge Mark and John review two papers that suggest higher levels of vitamin D via supplementation may slow our biologic clocks as measured by epigenetic methylation patterns. The implications are fascinating! YouTube link: https://youtu.be/O3UD62Pk9fE Papers reviewed: Vitamin D supplementation is associated with slower epigenetic aging https://pubmed.ncbi.nlm.nih.gov/35562… Effects of Vitamin D3 Supplementation on Epigenetic Aging in Overweight and Obese African Americans With Suboptimal Vitamin D Status: A Randomized Clinical Trial https://pubmed.ncbi.nlm.nih.gov/30256…

Effects-of-Vitamin-D3-Supplementation-on-Epigenetic-Aging-in-Overweight-and-Obese-African-Americans-With-Suboptimal-Vitamin-D-Status-A-Randomized-Clinical-TrialDownload

Can Healthy Lifestyle Regress Biologic Age?

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In this episode of The Health Edge Mark and John review a recently published paper affirming proof of concept: healthy lifestyle may in fact reverse biologic aging or slow “biologic clocks” via epigenetic methylation patterns. 


Potential reversal of epigenetic age using a diet and lifestyle intervention: a pilot randomized clinical trial

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8064200/

You Tube video can be seen here:

https://www.youtube.com/watch?v=MQahbN4pzxI&t=2s&ab_channel=TheHealthEdge