3 thoughts on “Is the microbiome a better predictor of chronic disease than the genome?”

    • Mark Pettus

      Hi Nancy,
      I do think the BRCA gene is in it’s own category and important, particularly for women with positive family histories of breast cancer (and /or ovarian cancer). As I’m sure you know, what to do with a positive test is very challenging and very personal as one “hedges” the odds. Interestingly, have positive BRCA in 2020 carries higher risk than what was suggested many years ago when the test first emerged. The suggestion is that the environment, particularly with the ubiquitous estrogen and endocrine disrupting toxins, is a major driver of disease risk.
      Warmest regards,
      Mark Pettus

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  2. Get Qoral Health

    includes a multi-disciplinary group to discover evolutionary mechanisms and understand spreading of antibiotic resistance in human pathogens. Metagenomic sequencing and functional metagenomic selections are used to map the human reservoir of antibiotic resistance genes (the resistome), to predict gene flow between different reservoirs and predict future resistance trends. The human gut microbiome has also been shown to be sensitive to non-antibiotic drugs. A study screening more than 1,000 marketed, non-antibiotic drugs found that 24% of these drugs could significantly change the composition of the gut microbiome (Maier et al., 2018 ). Following these findings, more research is needed on drug-microbiome interactions, side-effect control, drug repurposing, and the influence on antibiotic resistance.

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