Sodium Restriction and Insulin Resistance

In this episode of The Health Edge Mark and John review a recent paper drawing connections between excessive sodium restriction and insulin resistance. This adds to a growing body of research suggesting the restriction of sodium below 3-4 gms/day may in fact add to cardiometabolic risk. Current guidelines of 2300 mg/day or less fall well below these levels.


Erythritol and Cardiovascular Risk: Is there a real concern here?

In this Health Edge podcast recording, Mark and John review a recent paper that drew a strong relationship between erythritol levels in the blood with major adverse cardiovascular (MACE) events. Mark and John anayize the study and offer perspective. https://www.nature.com/articles/s4159… Another recent review of risks and benefits of erythritol. https://www.ncbi.nlm.nih.gov/pmc/arti…



Time Under the Load:The critical relationship between muscle mass, cognition and all-cause mortality

In this episode of the Health Edge, mark and John review two important studies. The first is a systematic review/meta analysis that clearly links loss of lean body mass (sarcopenia) with all-cause mortality and cardiovascular disease risk. The second paper reviews the underlying mechanisms that link lower muscle mass with greater risk of cognitive decline with aging. https://bjsm.bmj.com/content/56/13/755.info
https://pubmed.ncbi.nlm.nih.gov/35661882/

Alzheimer’s and Mild Cognitive Impairment: Is this epidemic a one-way street?

Few age-related diseases are more devastating than Alzheimer’s. A recent study from Columbia University suggests in individuals 65+ years of age, 10% have a dementia diagnosis and almost 25% have a diagnosis of MCI or mild cognitive decline. For the 90+ age demographic, over 30% have a dementia diagnosis. The costs to the individuals and those who care for them is staggering. In this recording, mark and John review the data from this paper (Annals of Neurology October 2022) and offer a different perspective on how to prevent, what today, feels like a one-way street.



Cardiovascular Aging and Longevity

Cardiovascular disease continues to be the #1 cause of mortality in the US and around the world. In this episode of The Health Edge, Mark and John review a paper that begins to address why it is that as we age, our risk for cardiovascular disease (CVD) and all other “age-related diseases” goes up dramatically. In this 2021 paper from the Journal of The American College of Cardiology, inhabitants of the Ikaria Island in Greece, a Blue Zone culture demonstrate lower levels of age-related changes e.g. inflammation, high insulin, short telomeres and offers many reasons for lower CVD risk, mortality and expanded healthspan.


The Omega-6 to Omega-3 Fat Ratio as a Predictor of Health and Longevity

In this recording of The Health Edge, Mark and John discuss the importance of dietary intake and sources of omega 6 and omega 3 fats. An abundance of epidemiological and clinical trials suggest high ratios of O-6/O-3 drive increased inflammation, oxidative stress and are associated with increased cardiovascular and all-cause mortality. Mark and John look at the biochemistry and some clinical trials that support avoidance of processed omega-6 vegetable oils and encourage more whole omega-3 sources.
Audio Recording