In this episode of The Health Edge Mark and John discuss the relationship between diet, TMAO (trimethylamine-N-oxide), and cardiovascular risk association. With far more questions than answers, we see agin the central role that the microbiome plays in the connections between nutrition and health. TMAO is found in high concentrations in salt water fish. TMAO is also formed by conversion in the gut by bacterial transformation of foods high in choline and carnitine such as eggs and red meats. The liver produces more TMAO in states of inflammation and insulin resistance from these foods, contingent on the diversity of the biome.

TMAO Review

Portune_et_al-2017-Molecular_Nutrition__Food_Research

Cho_et_al-2017-Molecular_Nutrition__Food_Research

Save the date: Health Edge Rejuvenation Retreat

La Montana Azul, Costa Rica

December 2-6, 2018

In this episode of the Health Edge Mark and John discuss some recent public controversy linking coffee with acrylamide and potential health concerns.

John Bagnulo PhD, MPH Blog on Coffee and Acrylamide

Jay Brault Commentary of Coffee, Acrylamide and Anti-Oxidants

Occurrence of acrylamide carcinogen in Arabic coffee Qahwa, coffee and tea from Saudi Arabian market

Coffee consumption and health- umbrella review of meta-analyses of multiple health outcomes

In this episode of The Health Edge Mark and John review a recent study linking alcohol intake with health outcomes. This Lancet study sheds a different light than what current recommendations in the US suggest is a safe threshold.

Lancet April 2018: Risk thresholds for alcohol consumption- combined analysis of individual-participant data for 599912 current drinkers in 83 prospective studies

In this episode of The Health Edge Mark and John discuss the critical importance of Vitamin K2, the forgotten vitamin. They review food sources, mechanisms of action and clinical research that supports the link between healthy vitamin K intake (100-200 mcg/day) and reductions in risk of osteoporosis, cardiovascular disease and cancer.

Rotterdam Study

Coronary Calcium

Vitamin K2 and Vascular Calcification

Vitamin K2 and Bone Health

Chris Masterjohn PhD Vitamin K2 Sources/Resources

Vitamins K1 and K2- The Emerging Group of Vitamins Required for Human Health

In this episode of The Health Edge Mark and John share some thoughts on the importance of trace minerals e.g. Boron, Selenium and Chromium and health.

In this episode of The Health Edge Mark and John discuss the importance of balancing protein needs.

Insulin-like growth factor-(IGF)-axis, inflammation, and glucose intolerance among older adults

Human conditions of insulin-like growth factor-I (IGF-I) deficiency

Both Low and High Serum IGF-I Levels Associate with Cancer Mortality in Older Men

Red Meat CVD Meta 2010

Circulating Insulin-Like Growth Factor I Mediates Effects of Exercise on the Brain

In this episode of The Health Edge Mark and John discuss some recent medical headlines of interest.

In this recording of The Health Edge John and Mark reflect on bile acid research. Their discussion explores the role of bile acids in human health and how diet, the gut microbiome, dysbiosis, gut permeability and bile acid signaling are connected in health and disease.

Bile Acid Metabolism and Signaling

Bile Acids and Dysbiosis in Non-Alcoholic Fatty Liver Disease

Evolutionary and Functional Diversification of the Vitamin D Receptor-Lithocholic Acid Partnership

The brain is not the source of consciousness. Consciousness is the source of the brain.

In this episode of The Health Edge John and Mark share some thoughts of the emerging research in consciousness, unified field theory, reality and how it shapes our experiences of life. They share some reflections on consciousness and health based on the cutting-edge work of Amit Goswami PhD, Nassim Haramein PhD, and Rupert Sheldrake PhD.

Amit Goswami

Rupert Sheldrake

Nassim Haramein

Recently I was interviewed on The Lo-Carb Paleo Show. It was great fun and wonderful to connect with like-minded members of the tribe!

Lo-Carb Paleo Recording