In this episode of The Health Edge Mark and John discuss the metabolic disruptors that increase the risk of Alzheimer’s and other “brain-related diseases”. The explore lifestyle interventions proven to restore many of these risk factors. Might Alzheimer’s be preventable or reversible? The research is suggesting a very surprising answer!

B-OH Butyrate and NLRP3 Inflammasome

Health Benefits of Nutritional Ketosis

Nutritional Mental Health 2015

PowerPoint on Core Imbalances Influencing Mind and Mood

MMF metabolic Tune Up

Neuropeptides and microbiota

Bredesen-reversing Alzheimers

In this episode of The Health Edge Mark and John discuss the connection between mitochondrial function and the risk-progression of many chronic complex diseases. They explore the many “environmental” drivers and offer some lifestyle interventions to improve mitochondrial reserve-resilience.

Mitochondrial Cocktail Podcast

In this episode of The Health Edge Mark and John discuss protein intake, sources, and health. They touch on:

• How much protein is sufficient for most
• What are the differences between plant and animal protein sources
• What are the benefits and risks of IGF-1 from a health perspective

Insulin, IGF-1 and Cancer

Red Meat CVD Meta 2010

Meat consumption and mortality – results from the European Prospective Investigation into Cancer and Nutrition

Both Low and High Serum IGF-I Levels Associate with Cancer Mortality in Older Men

Insulin-Like Growth Factor I, IGF-Binding Protein 3, and Lung Cancer Risk in a Prospective Study of Men in China

Meta-Analysis and Dose-Response Metaregression- Circulating Insulin-Like Growth Factor I (IGF-I) and Mortality

Circulating Insulin-Like Growth Factor I Mediates Effects of Exercise on the Brain

Human conditions of insulin-like growth factor-I (IGF-I) deficiencyIGF-1 promotes the development and cytotoxic activity of human NK cellsInsulin-like growth factor 1 (IGF1), IGF binding protein 3 (IGFBP3), and breast cancer risk- pooled individual data analysis of 17

prospective studiesDemonstrated brain insulin resistance in Alzheimer’s disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive declineInsulin-like growth factor-(IGF)-axis, inflammation, and glucose intolerance among older adults

In this episode of The health Edge Mark and John discuss the critical role magnesium plays in human health and resilience. They discuss testing, best food sources for magnesium and supplement consideration.

In this episode of The Health Edge Mark and John discuss the inherent limitations of looking at exercise simply as a “caloric burn” endeavor.

In this episode of The Health Edge Mark and John review some popular dietary myths.

In this episode of The Health Edge Mark and John discuss the health concerns with gluten-containing grains.

In this episode of The Health Edge Mark and John discuss the importance of advanced glycolsylated end-products (AGE molecules). They explore the epidemiology and mechanisms that connect AGEs to chronic complex disease. They conclude with lifestyle strategies that can lower AGE burden and improve AGE management.

Dietary Advanced Glycation End Products and Risk Factors for Chronic Disease- A Systematic Review of Randomised Controlled Trials

Elevated Serum Advanced Glycation Endpr…Between Healthy and Unhealthy Obesity?

Advanced glycation end products and their circulating receptors predict cardiovascular disease mortality in older communitydwelling women

In this episode of The Health Edge Mark and John discuss the fascinating topic of light and health and it’s many impacts on human biology and health.

In this episode of The Health Edge Mark and John review the epidemiology of hypertension and the importance of recognition and optimal management for health and risk reduction.