Curious about natural alternatives to expensive GLP-1 medications like Ozempic? Dr. Mark Pettus unveils powerful nutritional strategies to boost your body’s own GLP-1 production for improved metabolic health and sustainable weight management.

This eye-opening presentation dives into the fascinating relationship between your diet, gut microbiome, and GLP-1 production. Dr. Pettus, a kidney and integrative medicine specialist with 40 years of medical experience, explains how quality protein, healthy fats, fiber-rich foods, and even bitter-tasting ingredients can stimulate your natural GLP-1 pathways without prescription medications.

You’ll discover why the timing of your meals and exposure to natural light dramatically impacts hormone production, and how simple lifestyle adjustments can synchronize your circadian rhythms for optimal metabolic health. Dr. Pettus challenges conventional nutritional wisdom with evidence-based perspectives on protein requirements, healthy fats, and the critical importance of preserving muscle mass during weight loss.

Whether you’re currently taking GLP-1 medications and seeking complementary strategies, looking for natural alternatives, or simply interested in optimizing your metabolic health, this webinar provides practical, accessible approaches based on cutting-edge nutritional science. Learn how to work with your body’s natural hormonal systems rather than bypassing them, potentially reducing your dependence on expensive pharmaceutical interventions while improving your overall health.

Take control of your metabolic health through these natural nutritional strategies to enhance your body’s own GLP-1 production. Visit Dr. Pettus’ website www.thehealthedgepodcast.com for the video and slide deck.

For amazing GLP-1 inducing meals ready to eat (MREs) from Essential provisions, go to: https://essentialprovisions.com/collections/meals-ready-to-eat-mre

GLP-1 Nutritional Strategies Power Point Slides

Chronic inflammation has emerged as one of the most significant drivers behind virtually all modern health challenges. In this thought-provoking exploration, Dr. Mark Pettus reveals why researchers now refer to inflammation as “the cause of everything” and introduces the concept of “inflammaging” – how chronic inflammation accelerates biological aging and compromises quality of life.

Dr. Pettus takes us beyond conventional medical thinking to understand that while inflammation is an essential protective mechanism, it becomes destructive when chronically activated. Our modern environment, filled with processed foods, chronic stress, environmental toxins, and disrupted sleep patterns, keeps this system perpetually triggered, setting the stage for everything from diabetes to autoimmune conditions.

The most eye-opening revelations come when Dr. Pettis challenges popular nutritional dogma. He explains why fat has been unfairly vilified while highlighting how the standard American diet—dominated by processed carbohydrates and industrial seed oils—creates the perfect inflammatory storm. You’ll discover why quality animal proteins and fats may be critical anti-inflammatory allies while learning how to identify truly nutritious foods that align with your biology.

Beyond nutrition, you’ll gain practical insights into creating a comprehensive anti-inflammatory lifestyle through improved sleep, stress management, movement, and perhaps most surprisingly, through cultivating self-love and meaningful connections. Dr. Pettus shares specific testing recommendations to objectively measure your inflammation levels and track your progress.

Whether you’re dealing with chronic health challenges, carrying extra weight, struggling with energy levels, or simply want to optimize your health span, this presentation offers a refreshing perspective that empowers you to address root causes rather than merely managing symptoms. Take the first step toward creating an anti-inflammatory lifestyle by implementing these evidence-based strategies today.

For video recording and slide deck go to www.thehealthedgepodcast.com

For Essential Provisions Nutritional Meals Ready to Eat (MREs) go to www.essentialprovisions.com

Audio Recording

Prepare to have your understanding of genetics completely transformed. The revolutionary science of epigenetics reveals that you’re not simply a prisoner of your DNA – you’re actively participating in how your genes express themselves through every choice you make.

Dr. Mark Pettus takes us on a fascinating journey through this emerging field that bridges the gap between fate and free will. Drawing on cutting-edge research and decades of clinical experience, he explains how our modern environment creates a profound mismatch with our ancient genetic template, setting the stage for chronic disease. The 21st century human faces challenges our ancestors never encountered – from ultra-processed foods to artificial lighting to environmental toxins – all triggering genetic expressions incompatible with optimal health.

The most empowering revelation? These expressions can change in real-time based on lifestyle choices. Within hours of consuming whole foods rather than processed ones, gene switches flip from promoting inflammation to reducing it. Regular movement, quality sleep, meaningful relationships, and even our thought patterns all influence our “book of life” at the molecular level. Dr. Pettis shares compelling research showing how maternal stress during pregnancy alters offspring epigenetics for decades, how indigenous populations saw 500% increases in diabetes within a generation after adopting Western lifestyles, and how we can potentially reverse our biological clocks through targeted lifestyle changes.

Discover why Blue Zone populations maintain extraordinary health into their 100s and how you can implement their wisdom into your modern life. This isn’t just about preventing disease – it’s about actively creating health by bringing your lifestyle into alignment with your evolutionary biology. The science is clear: you have far more control over your genetic expression than previously imagined. What will you write in your book of life?

Essential Provisions whole foods meals ready to eat (MREs) at www.essentialprovisions.com

Epigenetics Slide Deck

In this episode of The Health Edge Mark Pettus MD and John Bagnulo PhD, MPH review the compelling research linking creatine supplementation with important health outcomes.

Audio Below

Video Below

References

Common questions and misconceptions about creatine supplementation- what does the scientific evidence really show?

Effect of Creatine Monohydrate Supplementation on Macro- and Microvascular Endothelial Function in Older Adults- A Pilot Study

Effects of Creatine Supplementation and Resistance Training on Muscle Strength Gains in Adults <50 Years of Age- A Systematic Review and Meta-Analysis

Effects of Creatine Supplementation on Brain Function and Health

Effects of creatine supplementation on memory in healthy individuals- a systematic review and meta-analysis of randomized controlled trials copy

Unlock the secrets to a healthier, longer life by mastering the science behind protein intake. Discover the critical role of animal protein in maintaining lean body mass, boosting metabolic health, and combating age-related muscle loss. We challenge traditional views and outdated guidelines, bringing you insights from recent research and experts in the field to help you reassess the power of protein in your diet.

With less than 10% of Americans achieving optimal metabolic health, it’s time to rethink how much protein we really need. We explore groundbreaking studies by Dr. Luke von Loon and others that highlight the benefits of higher protein consumption for muscle synthesis, lasting well beyond 24 hours. By understanding how our ancestors thrived on protein-rich diets, you’ll gain a new appreciation for why your body efficiently uses protein and how it can transform your health and physique.

Dive deeper into the specifics of protein optimization, as we discuss the ideal range of 1.2-1.6 g/kg/day for maintenance and up to 1.6 to 2+ grams per kilogram per day for anabolic muscle growth and strength. Learn about the superior amino acid profiles in animal proteins and the essential role of branched-chain amino acids and potassium. We also cover the benefits of creatine and how word-of-mouth communication can be a powerful tool for sharing these life-changing insights. Embrace a diet rich in animal protein and healthy fats, while cutting out sugars and processed carbs, to achieve a more vibrant, healthier you.

Association of low muscle mass and obesity with increased all-cause and cardiovascular disease mortality in US adults

Association of muscle wasting with mortality risk among adults- A systematic review and meta-analysis of prospective studies

Associations of Muscle Mass and Strength with All-Cause Mortality among US Older Adults

Low skeletal muscle mass index and all-cause mortality risk in adults- A systematic review and meta-analysis of prospective cohort studies

Muscle Mass Index as a Predictor of Longevity in Older-Adults

Skeletal Muscle Mass as a Mortality Predictor among Nonagenarians and Centenarians- A Prospective Cohort Study

Strength as a Predictor of Longevity- Compelling Evidence

The prevalence of sarcopenia in communitydwelling older adults, an exploration of differences between studies and within definitions- a systematic review and meta-analyses

Sarcopenia PPT slide deck

In this first Health Edge podcast of 2025, Mark Pettus MD and John Bagnulo PhD, MPH review a 2024 study published in The Journal of Nutrition.

https://www.sciencedirect.com/science/article/abs/pii/S002231662400289X?via%3Dihub

Audio Recording

Dr. Pettus’ 2024 OLLI Innovative Trends in Aging and Longevity You Tube Recording

Innovative Trends in Aging and Longevity Science: “The future ain’t what it used to be.” In this webinar Dr. Mark Pettus will explore some of the most exciting trends in aging and longevity research. He will translate this science to promote actionable lifestyle medicine considerations that can be leveraged today. Themes will include: Reprogramming epigenetic biologic clocks through lifestyle change. Understanding the concept of “escape velocity” as an aspiration for aging in a more youthful way and expanding health span. Rethinking nutritional science that has guided how we perceive what is “good” for us as we age. Top 5 health span lifestyle considerations….no adult left behind. Dr. Pettus currently serves as Chief Medical Officer for Preventia Inc, providing mental health telehealth resources and coaching to colleges and universities. 21st Century Medicine 2024 Virtual Lecture Series A Four-Part Introduction to a New Approach to Medicine The intersection of the fields of genetics, artificial intelligence and medicine will have enormous impacts on human health and lifespans in the coming decades. Extraordinary research is not only guiding the progress made in treating individual diseases—cancer, sickle cell anemia, heart disease, diabetes, but also the aging process and human longevity. Changes in medicine and research will impact physician/patient interaction, our health, and of course, the cutting edge of laboratory science.

Dr. Pettus’ PowerPoint Slide Deck

In this Health Edge recording, Mark describes a model of integrative health-lifestyle medicine that is distinctly different from current allopathic disease-based models. He examines the metabolic perfect storm of insulin resistance and inflammation as passports to accelerated aging, chronic complex disease risk and poor quality of life or healthspan.

Insulin Resistance PowerPoint Slides

In this episode of the Health Edge I review a recent meta-analysis examining the magnitude of cardiovascular benefit from taking statins for elevated LDL in both primary and secondary prevention.

JAMA Intern Med. 2022;182(5):474-481. doi:10.1001/jamainternmed.2022.0134 Published online March 14, 2022.
https://pubmed.ncbi.nlm.nih.gov/35285…

Do you ever feel like everything you’ve been told about healthy eating seems to be teetering on the edge of being overturned?  Welcome to a mind-bending exploration where we question the status quo, particularly the demonization of full fat dairy and saturated fats. I’m diving deep into a groundbreaking study suggesting that pentadecanoic acid, a saturated fat found in full-fat dairy could actually promote health and contribute to our longevity. We challenge the shortcomings in the traditional medical model and its ability to promote health, and ponder the rapid expansion of knowledge in the information age.
Our journey continues as we venture into another exciting discussion on the potential essential role that pentadecanoic acid plays in our bodies. A compelling study indicates that a deficiency of this saturated fat could contribute to chronic diseases. We’re not trying to persuade you to change your dietary habits overnight, but rather, we invite you to question, learn, and make informed decisions about your health. As we wrap up, we highlight the importance of natural, whole foods in our diet and delve into how our modern lifestyle could be impacting our health. So, are you ready to embark on this journey into the world of saturated fats, dairy, and optimal health?

Dairy Fat and Health PowerPoint slide deck