In this episode of The Health Edge Mark and John discuss the research linking lifestyle with breast cancer risk and prognosis.

Pettus-BreastCancerConf

VitD and Breast CA

References Breast Cancer Risk-Survival Diabetes

References – Mindfulness Breast Cancer

References – Inflammation and Breast Cancer

Insulin resistance and breast ca

Obesity and cancer mechanisms Nature Reviews Endocrin 2014 p455-

Environmental Working Group

In this episode of The Health Edge Mark and John discuss the current research linking the microbiome to human health. They review why we have fewer and less diverse “Fellow Travelers” and how we can begin to think about restoring this critical ecosystem legacy.

Restoring Microbiome

Mayo Human Health

Immune modulators

Gut-Arthritis

Blaser Micrbiome Reolution

Cell Host Microbe 2017 p84-Dysbiosis and disease

Microbiome and neurotransmitters

Masters of Host Development and Physiology

Microbiome and human health

Sonnenburg-Fiber and Microbiota health Cell

Personalized Nutrition Glycemic Response Cell 2015

Probiotics and Inflammation

Fermented foods, microbiota and mental health

Neuropeptides and microbiota

Comparison with ancestral diets suggests dense acellular carbohydrates promote an inflammatory microbiota, and may be the primary dietary cause of leptin resistance and obesity.

In this episode of The Health Edge Mark and John discuss the metabolic disruptors that increase the risk of Alzheimer’s and other “brain-related diseases”. The explore lifestyle interventions proven to restore many of these risk factors. Might Alzheimer’s be preventable or reversible? The research is suggesting a very surprising answer!

B-OH Butyrate and NLRP3 Inflammasome

Health Benefits of Nutritional Ketosis

Nutritional Mental Health 2015

PowerPoint on Core Imbalances Influencing Mind and Mood

MMF metabolic Tune Up

Neuropeptides and microbiota

Bredesen-reversing Alzheimers

In this episode of The Health Edge Mark and John discuss the connection between mitochondrial function and the risk-progression of many chronic complex diseases. They explore the many “environmental” drivers and offer some lifestyle interventions to improve mitochondrial reserve-resilience.

Mitochondrial Cocktail Podcast

In this episode of The Health Edge Mark and John discuss protein intake, sources, and health. They touch on:

• How much protein is sufficient for most
• What are the differences between plant and animal protein sources
• What are the benefits and risks of IGF-1 from a health perspective

Insulin, IGF-1 and Cancer

Red Meat CVD Meta 2010

Meat consumption and mortality – results from the European Prospective Investigation into Cancer and Nutrition

Both Low and High Serum IGF-I Levels Associate with Cancer Mortality in Older Men

Insulin-Like Growth Factor I, IGF-Binding Protein 3, and Lung Cancer Risk in a Prospective Study of Men in China

Meta-Analysis and Dose-Response Metaregression- Circulating Insulin-Like Growth Factor I (IGF-I) and Mortality

Circulating Insulin-Like Growth Factor I Mediates Effects of Exercise on the Brain

Human conditions of insulin-like growth factor-I (IGF-I) deficiencyIGF-1 promotes the development and cytotoxic activity of human NK cellsInsulin-like growth factor 1 (IGF1), IGF binding protein 3 (IGFBP3), and breast cancer risk- pooled individual data analysis of 17

prospective studiesDemonstrated brain insulin resistance in Alzheimer’s disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive declineInsulin-like growth factor-(IGF)-axis, inflammation, and glucose intolerance among older adults